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Fifteen-Piconewton Force Detection from Neural Growth Cones Using Nanowire Arrays

Författare:
Publiceringsår: 2010
Språk: Engelska
Sidor: 782-787
Publikation/Tidskrift/Serie: Nano Letters
Volym: 10
Nummer: 3
Dokumenttyp: Artikel
Förlag: American Chemical Society

Sammanfattning

We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mu m. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy, Forces down to 15 pN were measured on neural growth cones, showing that this method can be used to study the Fine details of growth-cone dynamics.

Disputation

Nyckelord

  • Physics and Astronomy
  • Biology and Life Sciences
  • neuron
  • nanowire
  • picoNewton
  • Mechanosensing
  • cellular force

Övriga

Published
Yes
  • ISSN: 1530-6984

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