Fifteen-Piconewton Force Detection from Neural Growth Cones Using Nanowire Arrays

Summary, in English

We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mu m. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy, Forces down to 15 pN were measured on neural growth cones, showing that this method can be used to study the Fine details of growth-cone dynamics.

• Författare: Waldemar Hällström; Monica Lexholm; Dmitry Suyatin; Greger Hammarin; Dan Hessman; Lars Samuelson; Lars Montelius; Martin Kanje; Christelle Prinz
• Avdelning/ar: Fasta tillståndets fysik; Funktionell zoologi; NanoLund: Centre for Nanoscience
• Publiceringsår: 2010
• Språk: Engelska
• Sidor: 782-787
• Publikation/Tidskrift/Serie: Nano Letters
• Volym: 10
• Issue: 3
• Länkar: http://dx.doi.org/10.1021/nl902675h
• Dokumenttyp: Artikel i tidskrift
• Förlag: The American Chemical Society (ACS)
• Ämne: Nano Technology
• Nyckelord: neuron; nanowire; picoNewton; Mechanosensing; cellular force
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1530-6992