Identification of a NK/T cell restricted progenitor in adult bone marrow contributing to bone marrow and thymic-dependent NK cells.
Volym: May 4
Although bone marrow (BM) is the main site of NK cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK and T cell development in adult hematopoiesis. To investigate whether a potential NK/T lineage restriction of multipotent progenitors might take place already in the BM, we tested the full lineage potentials of NK cell progenitors (NKPs) in adult BM. Notably, while Lin(-)CD122(+)NK1.1(-)DX5(-) NKPs failed to commit to the B and myeloid lineages, they sustained a combined NK and T cell potential, in vivo, and in vitro at the single cell level. Whereas T cell development from NK/T progenitors is Notch-dependent, their contribution to thymic and BM NK cells remains Notch-independent. These findings demonstrate the existence of bi-potent NK/T cell progenitors in adult BM.
- ISSN: 1528-0020