Du är här

Nucleoside phosphorylases from clostridium perfringens in the synthesis of 2',3'-dideoxyinosine.

Författare:
  • Stig Christoffersen
  • Immacolata Serra
  • M Terreni
  • Jure Piskur (Professor)
Publiceringsår: 2010
Språk: Engelska
Sidor: 445-448
Publikation/Tidskrift/Serie: Nucleosides, nucleotides & nucleic acids
Volym: 29
Nummer: 4-6
Dokumenttyp: Artikel
Förlag: Taylor & Francis Group

Sammanfattning

Four Clostridium perfringens phosphorylases were subcloned, overexpressed and analyzed for their substrate specificity. DeoD(1) and PunA could use a variety of purine substrates, including an antiviral drug 2',3'-dideoxyinosine (ddI). In one-pot synthesis using Clostridium phosphorylases, 2',3'-dideoxyuridine and hypoxanthine were converted to ddI at yield of about 30%.

Disputation

Nyckelord

  • Biology and Life Sciences

Övriga

Published
Yes
  • ISSN: 1532-2335

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

LERU logotype U21 logotype

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen