Ribosylurea accumulates in yeast urc4 mutants.
Författare
Summary, in English
Yeast Saccharomyces (Lachancea) kluyveri urc4 mutants, unable to grow on uracil, biotransformed (14)C(2)-uracil into two labeled compounds, as detected by high performance liquid chromatography (HPLC). These two compounds could also be obtained following organic synthesis of ribosylurea. This finding demonstrates that in the URC pyrimidine degradation pathway, the opening of the uracil ring takes place when uracil is attached to the ribose moiety. Ribosylurea has not been reported in the cell metabolism before and the two observed compounds likely represent an equilibrium mixture of the pyranosyl and furanosyl forms.
Avdelning/ar
Publiceringsår
2010
Språk
Engelska
Sidor
433-437
Publikation/Tidskrift/Serie
Nucleosides, Nucleotides & Nucleic Acids
Volym
29
Issue
4-6
Dokumenttyp
Artikel i tidskrift
Förlag
Taylor & Francis
Ämne
- Biological Sciences
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1525-7770