Functional in vitro characterisation of the androgen receptor GGN polymorphism.
Författare
Summary, in English
Superior androgen receptor (AR) function in subjects carrying a GGN repeat length of 23 (GGN23) has been indicated in vivo. Therefore, the activity of the AR carrying GGN23 combined with CAG22 was compared to the AR with GGN10, 24 and 27, respectively, in the presence of 0.1-100 nM testosterone or DHT. At 100 nM DHT, GGN24 showed 35% lower transactivating activity (95% [CI]: 20-50%) than GGN23. GGN10 and GGN27 also showed significantly less AR activity than GGN23 (mean differences [95% CI]: 54% [40-68%] and 58% [39-78%], respectively). The same trend was also observed at lower DHT concentrations. In response to R 188 1, GGN23 activity was significantly higher than for other lengths. ARs with other glutamine numbers than 23 have lower transactivating capacity in response to both testosterone and DHT. Congenital malformations and other signs of hypoandrogenism in subjects with AR gene GGN lengths other than 23 could, hence, be related to a lower AR activity.
Avdelning/ar
- Reproduktionsmedicin, Malmö
- Urological research, Malmö
Publiceringsår
2007
Språk
Engelska
Sidor
184-187
Publikation/Tidskrift/Serie
Molecular and Cellular Endocrinology
Volym
264
Issue
1-2
Fulltext
- Available as PDF - 482 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Endocrinology and Diabetes
Nyckelord
- polymorphism
- androgen receptor
- transcription
Status
Published
Forskningsgrupp
- Reproductive medicine, Malmö
- Urological research, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1872-8057