Interactions between Cationic Lipid Bilayers and Model Chromatin
Författare
Summary, in English
Complexes formed in mixtures of cationic liposomes of varying charge density and nucleosome core particles (NCPs) or nucleosome arrays have been characterized. Under most of the conditions studied, the lipids and NCPs or arrays formed lamellar structures similar to those obtained with the liposomes and pure DNA. Thus, the dissociation of DNA from the NCP or nucleosome array and the formation of a DNA-lipid complex is thermodynamically favored, which can likely be ascribed mainly to the gain in entropy on release of the small counterions. Only at very low liposome charge densities are there indications that the NCPs/arrays do not dissociate upon interaction with the lipid bilayers. The reported results can serve as a valuable reference point in investigations of biologically more relevant systems.
Avdelning/ar
Publiceringsår
2010
Språk
Engelska
Sidor
12488-12492
Publikation/Tidskrift/Serie
Langmuir
Volym
26
Issue
15
Dokumenttyp
Artikel i tidskrift
Förlag
The American Chemical Society (ACS)
Ämne
- Physical Chemistry
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0743-7463