Du är här

Detection of cardiac pathology: time intervals and spectral analysis.

Författare:
Publiceringsår: 2007
Språk: Engelska
Sidor: 1036-1042
Publikation/Tidskrift/Serie: Acta Paediatrica
Volym: 96
Nummer: 7
Dokumenttyp: Artikel
Förlag: Blackwell

Sammanfattning

AIM: To develop an objective diagnostic method that facilitates detection of noncyanotic congenital heart diseases. METHODS: Heart sounds and murmurs were recorded from 60 healthy children and 173 children with noncyanotic congenital heart disease. Time intervals were measured and spectrum of the systolic murmurs analyzed. Stepwise logistic regression analysis was used to distinguish physiological from pathological signals. The receiver operating characteristic (ROC) curve was plotted to show the classification performance of the model and the area under the curve (AUC) was calculated. The probability cut-off points for calculation of sensitivities and specificities were estimated. RESULTS: The distinguishing variables were the interval from the end of the first heart sound (S(1)) and the beginning of the systolic murmur, respiratory variation of the splitting of the second heart sound, intensity of the systolic murmur, and standard deviation of the interval from the end of the S(1) to the maximum intensity of the murmur. The AUC was 0.95, indicating an excellent classification performance of the model. The sensitivity of 95% and specificity of 72% was achieved at a probability cut-off point of 0.45. Significant cardiac defects were correctly classified. CONCLUSION: Interval measurements and spectral analysis can be used to confirm significant noncyanotic congenital heart diseases. Further development of the method is necessary to detect also insignificant heart defects.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • receiver operating characteristic curve
  • murmur classification
  • heart sounds
  • stepwise logistic
  • signal analysis
  • regression analysis

Övriga

Published
Yes
  • ISSN: 0803-5253

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

 

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen