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Cognitive function in young adults following intrauterine growth restriction with abnormal fetal aortic blood flow.

Publiceringsår: 2007
Språk: Engelska
Sidor: 614-618
Publikation/Tidskrift/Serie: Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
Volym: 29
Nummer: 6
Dokumenttyp: Artikel
Förlag: John Wiley & Sons, Ltd.

Sammanfattning

Objective
Intrauterine growth restriction (IUGR) is a recognized risk factor for neurological deficits later in life. Abnormal fetal blood flow in the presence of IUGR helps to distinguish fetuses with true growth impairment from those that are small but normally grown. This study aimed to evaluate the influence of IUGR with abnormal fetal blood flow on cognitive function and psychological development in young adults.
Methods
Cognitive capacity (Wechsler adult intelligence scale-III (WAIS-III)) and psychological development (symptom check-list and Wender Utah rating scale) were evaluated at 18 years of age in 19 subjects who had had IUGR (abnormal fetal blood flow in the descending aorta and birth weight small-for-gestational age) and in 23 control subjects who had had normal fetal aortic blood flow and birth weight appropriate-for-gestational age (AGA). School grades at 16 years of age were also recorded.
Results
The IUGR subjects had significantly lower results at 18 years of age in the combined subtests of the WAIS-III measuring executive cognitive functions (P = 0.03) and lower school grades at 16 years of age (P = 0.03) compared with the AGA group. IUGR subjects did not exhibit significantly more psychological distress symptoms.
Conclusion
IUGR with abnormal fetal blood flow is associated with impaired executive cognitive function in young adults.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • Social Sciences
  • fetal blood flow
  • long-term follow-up
  • psychological development
  • intrauterine growth restriction
  • small for gestational age
  • cognitive outcome

Övrigt

Published
Yes
  • ISSN: 0960-7692

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