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Cardiac output measured by electrical velocimetry in the CT suite correlates with coronary artery enhancement: A feasibility study

In English

Författare

Summary, in English

Background: Cardiac output (CO) is inversely related to vascular contrast medium (CM) enhancement during computed tomography (CT). Impedance cardiography with a new technique, electrical velocimetry (EV), may create opportunities to measure CO pre-examination for adaptation of CM injection parameters. Purpose: To relate CO EV measured by radiology staff to aortic attenuation as a measure of coronary artery attenuation during CT coronary angiography (CTCA), and to formulate a tentative statistical model to adapt CM injection parameters to CO. Material and Methods: CO EV was measured immediately before 100 kVp CTCA (64-multirow detector) in 27 patients with presumed coronary artery disease. For CTCA, 260 mg I/kg (maximum dosage weight: 8090 kg for womenmen) was injected intravenously during 12 s. Simple linear regression analysis was performed to explore the correlation between aortic attenuation (Hounsfield units, HU) and body weight, the influence of CO EV on aortic attenuation adjusted to injected CM dose rate (HU per mg Ikgs), and to establish a tentative formula on how to adapt CM injection parameters to CO EV and desired aortic attenuation. Results: The correlation between aortic attenuation and body weight was weak and non-significant (r --0.14 after outlier exclusion). A significant negative correlation (r --0.63) was found between aortic attenuation adjusted to injected CM dose rate (HU per mg Ikgs) and CO EV. The resulting formula, CM dose rate = CO EV x (aortic attenuation -240)55, made it possible to calculate CM volumes and injection rates at various COs and, for example, the present mean aortic attenuation (438 HU), injection time (12 s), CM concentration (320 mg Iml), and a certain body weight. Conclusion: EV makes it possible to measure CO in the CT suite before vascular examinations. Hence, CM doses may be decreased in low CO states to reduce the risk of CM-induced nephropathy without jeopardizing diagnostic quality and may be increased in high CO states to avoid poor enhancement.

Publiceringsår

2010

Språk

Engelska

Sidor

895-902

Publikation/Tidskrift/Serie

Acta Radiologica

Volym

51

Issue

8

Dokumenttyp

Artikel i tidskrift

Förlag

SAGE Publications

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • nephropathy
  • contrast medium-induced
  • Contrast enhancement
  • coronary angiography

Status

Published

Forskningsgrupp

  • Radiology Diagnostics, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1600-0455