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Primary aldosteronism among newly diagnosed and untreated hypertensive patients in a Swedish primary care area.

In English

Författare

Summary, in English

Abstract Objective. To evaluate the prevalence of primary aldosteronism (PA) in newly diagnosed and untreated hypertensive patients in primary care using the aldosterone/renin ratio (ARR), and to assess clinical and biochemical characteristics in patients with high and normal ARR. Design. Patient survey study. Setting and subjects. A total of 200 consecutive patients with newly diagnosed and untreated hypertension from six primary health care centres in Sweden were included. Main outcome measures. ARR was calculated from serum aldosterone and plasma renin concentrations. The cut-off level for ARR was 65. Patients with an increased ARR were considered for confirmatory testing with the fludrocortisone suppression test (FST), followed by adrenal computed tomographic radiology (CT) and adrenal venous sampling (AVS). Results. Of 200 patients, 36 patients had an ARR > 65. Of these 36 patients, 11 patients had an incomplete aldosterone inhibition during FST. Three patients were diagnosed with an aldosterone producing adenoma (APA) and eight with bilateral adrenal hyperplasia (BHA). Except for moderately lower level of P-K in patients with an ARR > 65 and in patients with PA, there were no biochemical or clinical differences found among hypertensive patients with PA compared with patients without PA. Conclusion. Eleven of 200 evaluated patients (5.5%) were considered to have PA. The diagnosis of PA should therefore be considered in newly diagnosed hypertensive subjects and screening for the diagnosis is warranted.

Publiceringsår

2011

Språk

Engelska

Sidor

57-62

Publikation/Tidskrift/Serie

Scandinavian Journal of Primary Health Care

Volym

29

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Taylor & Francis

Ämne

  • Health Care Service and Management, Health Policy and Services and Health Economy

Status

Published

Forskningsgrupp

  • Family Medicine and Community Medicine

ISBN/ISSN/Övrigt

  • ISSN: 0281-3432