Meny

Javascript verkar inte påslaget? - Vissa delar av Lunds universitets webbplats fungerar inte optimalt utan javascript, kontrollera din webbläsares inställningar.
Du är här

Linking genetic mechanisms of heterozygosity-fitness correlations to footprints of selection at single loci

Författare:
  • Jakob C. Mueller
  • Joachim Hermisson
  • Juanita Olano-Marin
  • Bengt Hansson
  • Bart Kempenaers
Publiceringsår: 2011
Språk: Engelska
Sidor: 1-11
Publikation/Tidskrift/Serie: Evolutionary Ecology
Volym: 25
Nummer: 1
Dokumenttyp: Artikel
Förlag: Springer

Sammanfattning

Investigations of heterozygosity-fitness correlations (HFCs) are central to the understanding how genetic diversity is maintained in natural populations. Advanced genome-wide approaches will enrich the number of functional loci to be tested. We argue that a combined analysis of the genetic mechanisms of HFCs and selection signals at single loci will allow researchers to better understand the micro-evolutionary basis of HFCs. Different dominance relationships among the alleles at the locus can lead to positive, negative or null HFCs depending on the allele frequency distribution. These scenarios differ in the temporal stability of the HFCs and in the patterns of allele frequency changes over time. Here, we describe a simple theoretical framework that links the analyses of heterozygosity-fitness associations (ecological timescale) with tests for selection signals (evolutionary timescale). Different genomic footprints of selection can be expected for the different underlying genetic mechanisms of HFCs, and this information can be independently used for the classification of HFCs. We suggest that in addition to inbreeding and single-locus overdominant effects also loci under directional selection could play a significant role in the development of heterozygosity-fitness effects in large natural populations under recent or fluctuating ecological changes.

Disputation

Nyckelord

  • Biology and Life Sciences
  • Allelic dominance
  • Recessiveness
  • Microevolution
  • Partial selective
  • sweep
  • Balancing selection
  • Fluctuating selection

Övriga

Published
Yes
  • Molecular Ecology and Evolution Lab
  • ISSN: 0269-7653

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen