Dosimetry in patients with B-cell lymphoma treated with [90Y]ibritumomab tiuxetan or [131I]tositumomab.
Författare
Summary, in English
Radioimmunotherapy involves the use of radiolabeled monoclonal antibodies (MAbs) to treat malignancy. The therapeutic effect is determined by the radiopharmaceutical, the radiation absorbed dose and previous treatments. There are currently two approved radiopharmaceuticals for the treatment of B-cell lymphoma - the 90Y-labeled ibritumomab and the 131I-labeled tositumomab. Both are directed against CD20, albeit not against the same epitope. This paper summarizes current results of dose-responses for normal tissues and tumours of [131I]tositumomab and [90Y]ibritumomab tiuxetan, discusses them in the context of dosimetry methods used and highlights the assumptions being made in the different dosimetry methodologies. Moreover, we wish to point at the possibility of performing low-cost therapy bremsstrahlung imaging for [90Y]ibritumomab tiuxetan to confirm biodistribution, and possibly also for dosimetric calculations.
Avdelning/ar
- Medicinsk strålningsfysik, Lund
- Bröstcancer-genetik
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publiceringsår
2011
Språk
Engelska
Sidor
126-154
Publikation/Tidskrift/Serie
Quarterly Journal of Nuclear Medicine and Molecular Imaging
Volym
55
Issue
2
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Edizioni Minerva Medica
Ämne
- Radiology, Nuclear Medicine and Medical Imaging
- Cancer and Oncology
Nyckelord
- Lymphoma
- Dosimetry
- Antibodies
- monoclonal
- Radioimmunotherapy
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1824-4785