Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Standardization and Utilization of Biobank Resources in Clinical Protein Sciene with Examples of Emerging Applications

In English

Författare

Summary, in English

Biobanks are a major resource to access and measure biological constituents that can be used to monitor the status of health and disease, both in unique individual samples and within populations. Most “omic” activities rely on access to these collections of stored samples to provide the basis for establishing the ranges and frequencies of expression. Furthermore, information about the relative abundance and form of protein constituents found in stored samples provides an important historical index for comparative studies of inherited, epidemic, and developing disease. Standardizations of sample quality, form, and analysis are an important unmet need and requirement for gaining full benefit from collected samples. Coupled to this standard is the provision of annotation describing clinical status and metadata of measurements of clinical phenotype that characterizes the sample. Today we have not yet achieved consensus on how to collect, manage, and build biobank archives in order to reach goals where these efforts are translated into value for the patient. Several initiatives (OBBR, ISBER, BBMRI) that disseminate best practice examples for biobanking are expected to play an important role in ensuring the need to preserve the sample integrity of biosamples stored for periods that reach one or several decades. These developments will be of great value and importance to programs such as the Chromosome Human Protein Project (C-HPP) that will associate protein expression in healthy and disease states with genetic foci along of each of the human chromosomes.

Avdelning/ar

Publiceringsår

2012

Språk

Engelska

Sidor

5124-5134

Publikation/Tidskrift/Serie

Journal of Proteome Research

Volym

11

Issue

11

Dokumenttyp

Artikel i tidskrift

Förlag

The American Chemical Society (ACS)

Ämne

  • Cancer and Oncology

Nyckelord

  • Biobank
  • Healthcare
  • Disease
  • Biomarkers
  • Protein
  • Human Proteome Project
  • Biological specimen banks
  • Biological Specimen Banks/ethics
  • Biological Specimen Banks/legislation & jurisprudence
  • Biomedical Research/ethics
  • Ethical review
  • Government regulation
  • Humans
  • Informed consent
  • Tissue donors
  • Ethics

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1535-3893