Du är här

Allogeneic haematopoietic stem-cell transplantation with reduced intensity conditioning for advanced stage Hodgkin's lymphoma in Sweden: high incidence of post transplant lymphoproliferative disorder

Författare:
Publiceringsår: 2011
Språk: Engelska
Sidor: 870-875
Publikation/Tidskrift/Serie: Bone Marrow Transplantation
Volym: 46
Nummer: 6
Dokumenttyp: Artikel
Förlag: Nature Publishing Group

Sammanfattning

Allogeneic transplantation after reduced intensity conditioning (allo-RIC) is a treatment option for patients with Hodgkin's lymphoma (HL) relapsing after autologous transplantation. In all, 23 adult patients with HL underwent allo-RIC in Sweden between 2000 and 2007. The median number of previous treatment lines was five and 20 patients (87%) were previously autografted. TRM at 100 days and at 1 year was 13 and 22% respectively. Acute GVHD grades II-IV developed in 7 out of 23 patients (30%) and chronic GVHD in 10 out of 20 patients at risk (50%). The OS and EFS at three years was 59 and 27%, respectively. Four patients (17%) developed post transplant lymphoproliferative disease (PTLD) after a median time of 55 days (range 38-95); two of these patients later died. The study confirmed that allo-RIC is feasible, but associated with a substantial relapse rate: only 20% of the patients were still alive 7 years after the transplant. A finding of high incidence of PTLD needs to be confirmed in a larger trial that includes patients with non-HL and CLL. Bone Marrow Transplantation (2011) 46, 870-875; doi: 10.1038/bmt.2010.238; published online 18 October 2010

Disputation

Nyckelord

  • Medicine and Health Sciences
  • allogeneic
  • transplantation
  • Hodgkin's lymphoma
  • post transplant
  • lymphoproliferative disorder
  • reduced intensity conditioning

Övriga

Published
Yes
  • ISSN: 0268-3369

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

LERU logotype U21 logotype

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen