Allogeneic haematopoietic stem-cell transplantation with reduced intensity conditioning for advanced stage Hodgkin's lymphoma in Sweden: high incidence of post transplant lymphoproliferative disorder
Författare
Summary, in English
Allogeneic transplantation after reduced intensity conditioning (allo-RIC) is a treatment option for patients with Hodgkin's lymphoma (HL) relapsing after autologous transplantation. In all, 23 adult patients with HL underwent allo-RIC in Sweden between 2000 and 2007. The median number of previous treatment lines was five and 20 patients (87%) were previously autografted. TRM at 100 days and at 1 year was 13 and 22% respectively. Acute GVHD grades II-IV developed in 7 out of 23 patients (30%) and chronic GVHD in 10 out of 20 patients at risk (50%). The OS and EFS at three years was 59 and 27%, respectively. Four patients (17%) developed post transplant lymphoproliferative disease (PTLD) after a median time of 55 days (range 38-95); two of these patients later died. The study confirmed that allo-RIC is feasible, but associated with a substantial relapse rate: only 20% of the patients were still alive 7 years after the transplant. A finding of high incidence of PTLD needs to be confirmed in a larger trial that includes patients with non-HL and CLL. Bone Marrow Transplantation (2011) 46, 870-875; doi: 10.1038/bmt.2010.238; published online 18 October 2010
Avdelning/ar
Publiceringsår
2011
Språk
Engelska
Sidor
870-875
Publikation/Tidskrift/Serie
Bone Marrow Transplantation
Volym
46
Issue
6
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Cell and Molecular Biology
Nyckelord
- allogeneic
- transplantation
- Hodgkin's lymphoma
- post transplant
- lymphoproliferative disorder
- reduced intensity conditioning
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1476-5365