Expression of apolipoprotein M in human hepatocellular carcinoma tissues
Författare
Summary, in English
The present study examined mRNA levels and protein mass of apolipoprotein M (apoM) in human hepatocellular carcinoma (HCC) tissues and in the adjacent tissues. Plasma apoM levels in these HCC patients were also determined and compared to the normal subjects. The mean level of plasma apoM in the HCC patients was 0.61 +/- 0.30 OD mm(-2), which was significantly higher than that in the normal subjects 0.37 +/- 0.07 OD mm(-2) (P < 0.01). However, both apoM mRNA levels and apoM protein mass in the HCC tissues were significantly lower than in the adjacent tissues (P < 0.05). It is concluded that human hepatocellular carcinoma tissues had a reduced capacity to produce apoM than the adjacent non-tumor tissues. However, the plasma apoM levels were higher in the HCC patients than in normal subjects, which suggested that tissues adjacent to the tumors or extra-hepatic apoM production in the HCC patients may contribute to the higher plasma apoM levels in these patients. The clinical significance of apoM in relation to HCC still needs further investigation. (C) 2009 Published by Elsevier GmbH.
Avdelning/ar
Publiceringsår
2011
Språk
Engelska
Sidor
53-57
Publikation/Tidskrift/Serie
Acta Histochemica
Volym
113
Issue
1
Fulltext
- Available as PDF - 297 kB
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Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Biochemistry and Molecular Biology
Nyckelord
- Apolipoprotein M
- Hepatocellular carcinoma
- Immunohistochemistry
- Human
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0065-1281