The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs.
Författare
Summary, in English
Vault particles are conserved organelles implicated in multidrug resistance and intracellular transport. They contain three different proteins and non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from those in the canonical microRNA (miRNA) pathway. At least one of these svRNAs, svRNAb, associates with Argonaute proteins to guide sequence-specific cleavage and regulate gene expression similarly to miRNAs. We demonstrate that svRNAb downregulates CYP3A4, a key enzyme in drug metabolism. Our findings expand the repertoire of small regulatory RNAs and assign, for the first time, a function to vRNAs that may help explain the association between vault particles and drug resistance.
Publiceringsår
2009
Språk
Engelska
Sidor
1268-1271
Publikation/Tidskrift/Serie
Nature Cell Biology
Volym
11
Issue
10
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Cancer and Oncology
- Microbiology in the medical area
Status
Published
Forskningsgrupp
- Clinical Virology, Malmö
- Cancer and non coding RNA
ISBN/ISSN/Övrigt
- ISSN: 1465-7392