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Acute synovitis induced by preformed immune complexes

In English

Författare

Summary, in English

The morphology of acute immune complex (IC) elicited synovitis in rabbit knee joints was studied, as well as IC-induced leukocyte activation in vivo and in vitro. Acute synovitis was induced by intra-articular injection of in vitro preformed, complement activating bovine serum albumin (BSA)-anti-BSA IC. Within 30 min, migration of polymorphonuclear granulocytes (PMNGs) was observed. Scanning electron microscopy showed that adhering, apparently activated leukocytes were attached to the synovial lining, often forming clusters. Phagocytosis of IC was evident, as immunoglobulins were detected within the leukocyte cytoplasm by the direct immunofluorescence technique. At the peak accumulation of PMNGs, focal erosions of the synovial lining were observed. Later, monocytes and macrophages appeared and degenerated PMNGs were found, sometimes within the cytoplasm of large macrophages. Chemiluminescence experiments showed a maximum in vitro activation of leukocytes by complement activating IC formed near optimal precipitation proportions and in slight antigen excess, whereas IC in large antigen excess gave a smaller and later response.

Publiceringsår

1986

Språk

Engelska

Sidor

134-142

Publikation/Tidskrift/Serie

Scandinavian Journal of Rheumatology

Volym

15

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Taylor & Francis

Ämne

  • Rheumatology and Autoimmunity

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1502-7732