Publikationer
Long-term lead elimination from plasma and whole blood after poisoning.
Avdelning/ar:
Publiceringsår: 2012
Språk: Engelska
Sidor: 311-316
Publikation/Tidskrift/Serie: International archives of occupational and environmental health
Volym: 85
Fulltext:
Dokumenttyp: Artikel
Förlag: Springer
Sammanfattning
OBJECTIVE:
Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.
METHODS:
A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.
RESULTS:
P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.
CONCLUSION:
P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.
METHODS:
A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.
RESULTS:
P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.
CONCLUSION:
P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
Disputation
Nyckelord
- Medicine and Health Sciences
Övrigt
Published
Yes
The original publication is available at www.springerlink.com
- ISSN: 1432-1246
