Conjugated linoleic acid increased C-reactive protein in human subjects

Summary, in English

We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.

• Författare: A Smedman; S Basu; Stefan Jovinge; Gunilla Nordin Fredrikson; B Vessby
• Avdelning/ar: Stamcellscentrum (SCC); Kardiovaskulär forskning - immunitet och ateroskleros
• Publiceringsår: 2005
• Språk: Engelska
• Sidor: 791-795
• Publikation/Tidskrift/Serie: British Journal of Nutrition
• Volym: 94
• Issue: 5
• Länkar: http://dx.doi.org/10.1079/BJN20041419
• Dokumenttyp: Artikel i tidskrift
• Förlag: Cambridge University Press
• Ämne: Nutrition and Dietetics
• Nyckelord: tumour necrosis; conjugated linoleic acid; C-reactive protein; inflammation; factor-alpha
• Status: Published
• Forskningsgrupp: Cardiovascular Research - Immunity and Atherosclerosis
• ISBN/ISSN/Övrigt: ISSN: 1475-2662