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The role of p-c-Jun in survival and outgrowth of developing sensory neurons

Författare:
  • Charlotta Lindwall
  • Martin Kanje
Publiceringsår: 2005
Språk: Engelska
Sidor: 1655-1659
Publikation/Tidskrift/Serie: NEUROREPORT
Volym: 16
Nummer: 15
Dokumenttyp: Artikel
Förlag: Lippincott Williams & Wilkins

Sammanfattning

C-jun activation has been implicated not only in neuronal apoptosis, but also in survival and regeneration. This Janus facet of c-Jun activation could be related to neuronal cell type or to the developmental stage of the neuron. We investigated c-Jun activation in E18 sensory neurons. Cultures of rat dorsal root ganglia neurons were maintained with or without the addition of nerve growth factor or the c-Jun N-terminal kinase inhibitor, (D)-JNKII. Few dorsal root ganglia neurons survived nerve growth factor deprivation, whereas neurons supplied with nerve growth factor survived and exhibited extensive axonal outgrowth. Activated c-Jun was present in the nuclei of neurons with regenerating axons, but not in apoptotic neurons. c-Jun N-terminal kinase inhibition reduced the number of p-c-Jun immunoreactive and regenerating neurons, and increased cell death. Thus, activation of c-Jun seems to be required for survival and regeneration of developing sensory neurons.

Disputation

Nyckelord

  • Science General
  • nerve growth
  • dorsal root ganglia
  • development
  • c-Jun
  • (D)-JNKII
  • rat
  • factor

Övriga

Published
Yes
  • ISSN: 0959-4965

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