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New topics in bradykinin research.

In English

Författare

  • M Maurer
  • M Bader
  • M Bas
  • F Bossi
  • M Cicardi
  • M Cugno
  • P Howarth
  • A Kaplan
  • G Kojda
  • Fredrik Leeb-Lundberg
  • J Lötvall
  • M Magerl
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Summary, in English

To cite this article: Maurer M, Bader M, Bas M, Bossi F, Cicardi M, Cugno M, Howarth P, Kaplan A, Kojda G, Leeb-Lundberg F, Lötvall J, Magerl M. New topics in bradykinin research. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02686.x ABSTRACT: Bradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B(1) and B(2) receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The development of pharmacologically active substances, such as bradykinin receptor blockers, opens up new therapeutic options that require further research into bradykinin. This review presents current understanding surrounding the role of bradykinin in nonallergic angioedema and other conditions seen by allergists and emergency physicians, and its potential role as a therapeutic target.

Avdelning/ar

  • Drug Target Discovery

Publiceringsår

2011

Språk

Engelska

Sidor

1397-1406

Publikation/Tidskrift/Serie

Allergy

Volym

66

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Respiratory Medicine and Allergy

Status

Published

Forskningsgrupp

  • Drug Target Discovery

ISBN/ISSN/Övrigt

  • ISSN: 1398-9995