Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Design and clinical evaluation of robust PID control of propofol anesthesia in children

Författare

  • Klaske van Heusden
  • Guy A. Dumont
  • Kristian Soltesz
  • Christian L. Petersen
  • Aryannah Umedaly
  • Nicholas West
  • J. Mark Ansermino

Summary, in English

This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter- patient variability in the response to propofol infusion in the study population. The PID controller is tuned to achieve sufficient robustness margins for the identified uncertainty. 108 children were enrolled in the study, anesthesia was closed-loop controlled in 102 of these cases. Clinical evaluation of the system shows that closed-loop control of both induction and maintenance of anesthesia in children based on the WAVCNS index as a measure of clinical effect is feasible. A robustly tuned PID controller can accommodate the inter-patient variability in children and spontaneous breathing can be maintained in most subjects.

Publiceringsår

2014

Språk

Engelska

Sidor

491-501

Publikation/Tidskrift/Serie

IEEE Transactions on Control Systems Technology

Volym

22

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

IEEE - Institute of Electrical and Electronics Engineers Inc.

Ämne

  • Control Engineering

Nyckelord

  • anesthesia
  • robust control
  • clinical trials
  • PID control

Status

Published

Projekt

  • Anesthesia in Closed Loop
  • LCCC

Forskningsgrupp

  • LCCC

ISBN/ISSN/Övrigt

  • ISSN: 1558-0865