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Cancer incidence in 13811 patients skin tested for allergy

In English

Författare

  • NE Eriksson
  • Zoli Mikoczy
  • L Hagmar

Summary, in English

Aim. Several studies have shown a negative correlation between cancer and atopy-related diseases. There are also a few reports of a positive relationship. We wanted to further evaluate these relationships in a prospective study. Subjects and methods. The incidence of malignant diseases among adult patients with atopy-related diseases (asthma, rhinitis, urticaria, eczema etc; n=13811), who had been skin prick tested in 1976-1999 was compared with the incidence in the general population. Expected cancer incidence from the date of skin prick testing up to 1999 was obtained from cause-, sex-, calendar-year-, and 5-year-age-group specific incidence rates for the county. These rates were calculated from cancer incidence and population counts obtained from the Swedish Cancer Register. The 95% confidence intervals (CIs) for cause-specific standardized incidence ratios (SIRS) were calculated. Skin prick tests were performed with Dermatophagoides pteronyssinus, horse, dog, cat, timothy, mugwort, birch, and Cladosporium. Patients having one or several positive skin prick test reactions (>= 2+) were regarded as atopics. Results. 119 cases of cancer occurred among 6224 atopic individuals (SIR 1.0) compared with 216 cases (SIR 0.94, CI 0.82-1.08) among 6358 non-atopics. There was a slight excess of Hodgkin's lymphoma cases among atopic men (SIR 4.03, 95% CI 1-10.3), and of non Hodgkin lymphoma cases among atopic women (SIR 4.52, 95% CI 1.23-11.6). However, a large number of comparisons were made which can have caused random findings. Conclusions. The results showed no associations between atopy or allergic symptoms, and subsequent cancer risk, but supported the theory that type-I allergy is not related to cancer risk.

Publiceringsår

2005

Språk

Engelska

Sidor

161-166

Publikation/Tidskrift/Serie

Journal of Investigational Allergology & Clinical Immunology

Volym

15

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Hogrefe & Huber Publishers

Ämne

  • Environmental Health and Occupational Health

Nyckelord

  • cancer
  • atopy-related diseases
  • allergic rhinitis
  • allergy
  • asthma
  • skin prick test
  • malignancies

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1698-0808