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Cell-matrix interactions in muscle disease.

In English

Författare

Summary, in English

The extracellular matrix provides a solid scaffold and signals to cells through extracellular matrix receptors. The cell-matrix interactions are crucial for normal biological processes and when disrupted they may lead to pathological processes. In particular, the biological importance of extracellular matrix-cell membrane-cytoskeleton interactions in skeletal muscle is accentuated by the number of inherited muscle diseases caused by mutations in proteins conferring these interactions. In this review we will introduce laminins, collagens, dystroglycan, integrins, dystrophin and sarcoglycans. Mutations in corresponding genes cause various forms of muscular dystrophy. The muscle disorders will be presented as well as advances toward development of treatment. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Avdelning/ar

Publiceringsår

2012

Språk

Engelska

Sidor

200-218

Publikation/Tidskrift/Serie

Journal of Pathology

Volym

226

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Cell and Molecular Biology

Status

Published

Forskningsgrupp

  • Muscle Biology

ISBN/ISSN/Övrigt

  • ISSN: 0022-3417