Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

A dose-dependent dual effect of oestrogen on voiding in the male mouse?

In English

Författare

Summary, in English

To explore the effect of different degrees of oestrogenization on male voiding, by treating adult castrated and 5 alpha-dihydrotestosterone (DHT)-maintained male mice with different doses of oestrogens, as exposure of male mice to excessive amounts of oestrogens can cause bladder outlet obstruction (BOO); in addition, male mice lacking oestrogen receptor (ER)alpha (ERKO) or ER beta (BERKO) were studied to assess the importance of ER subtypes. Castrated, DHT-maintained adult mice were treated with 17 beta-oestradiol (E-2; 50 and 250 mu g/kg) or oestrone (E-1; 5, 50 and 500 mu g/kg) daily for 10 days. Control mice were treated only with the vehicle. BERKO and ERKO mice, and their wild-type littermates used as their controls, remained untreated. Under anaesthesia, the bladder and distal urethra were exposed to record simultaneously the bladder pressure and urinary flow rate from the distal urethra. E-2-treated mice showed obstructive voiding, seen as increased bladder pressure, decreased average flow rate and prolonged micturition time. This was also evident when a high dose (500 mu g/kg) of E-1 was used. After treatment with a dose of 50 mu g/kg, the urodynamic variables were similar to those in the control mice. Surprisingly, after treatment with a low dose (5 mu g/kg) all urodynamic variables improved. There was a minor increase in the bladder pressure in BERKO mice; ERKO mice had a significantly lower urinary flow rate. High doses of oestrogens caused BOO in castrated, DHT-maintained male mice. A small dose of E-1 had a positive effect on voiding, suggesting that oestrogens are needed for normal male voiding. Reduced urinary flow rates in ERKO mice suggest that oestrogen effects on voiding are mediated at least partly via ER alpha.

Publiceringsår

2005

Språk

Engelska

Sidor

1126-1130

Publikation/Tidskrift/Serie

BJU International

Volym

96

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Urology and Nephrology

Nyckelord

  • oestrone
  • oestradiol
  • bladder outlet obstruction
  • urodynamics
  • cystometry
  • male mouse

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1464-4096