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WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex

In English

Författare

  • Ram Kishor Yadav
  • Mariano Perales
  • Jeremy Gruel
  • Thomas Girke
  • Henrik Jönsson
  • G. Venugopala Reddy

Summary, in English

WUSCHEL (WUS) is a homeodomain transcription factor produced in cells of the niche/organizing center (OC) of shoot apical meristems. WUS specifies stem cell fate and also restricts its own levels by activating a negative regulator, CLAVATA3 (CLV3), in adjacent cells of the central zone (CZ). Here we show that the WUS protein, after being synthesized in cells of the OC, migrates into the CZ, where it activates CLV3 transcription by binding to its promoter elements. Using a computational model, we show that maintenance of the WUS gradient is essential to regulate stem cell number. Migration of a stem cell-inducing transcription factor into adjacent cells to activate a negative regulator, thereby restricting its own accumulation, is a theme that is unique to plant stem cell niches.

Publiceringsår

2011

Språk

Engelska

Sidor

2025-2030

Publikation/Tidskrift/Serie

Genes & Development

Volym

25

Issue

19

Dokumenttyp

Artikel i tidskrift

Förlag

Cold Spring Harbor Laboratory Press (CSHL)

Ämne

  • Genetics

Nyckelord

  • CLAVATA3
  • shoot apical meristem
  • CLAVATA1
  • central zone
  • niche

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1549-5477