Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties.

Summary, in English

Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H(2)papy) with VOSO(4) in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}(2) μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H(2)glysal) with VOSO(4) gives [(glysal)VO(H(2)O)] (2) and reaction of salicylamide (Hsalam) with VOSO(4) in methanol gives [(salam)(2)VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2-10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect.

• Författare: Jessica Nilsson; Albert A Shteinman; Eva Degerman; Eva A Enyedy; Tamás Kiss; Ulrich Behrens; Dieter Rehder; Ebbe Nordlander
• Avdelning/ar: Signaltransduktionsforskning; EXODIAB: Excellence of Diabetes Research in Sweden
• Publiceringsår: 2011
• Språk: Engelska
• Sidor: 1795-1800
• Publikation/Tidskrift/Serie: Journal of Inorganic Biochemistry
• Volym: 105
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/22056176?dopt=Abstract; http://dx.doi.org/10.1016/j.jinorgbio.2011.09.022
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Biochemistry and Molecular Biology
• Status: Published
• Forskningsgrupp: Insulin Signal Transduction
• ISBN/ISSN/Övrigt: ISSN: 1873-3344