3-Hydroxy fatty acids in saliva as diagnostic markers in chronic periodontitis

Summary, in English

Saturated straight- and branched-chain 3-hydroxy fatty acids (3-OH FAs) of 10-18 carbon chain lengths were determined in saliva from 27 individuals with chronic periodontitis and 18 healthy individuals by using gas chromatography-tandem mass spectrometry. Of the 14 different 3-OH FAs detected, 3-OH-C-i17:0 was the most abundant in the periodontitis samples while 3-OH-C-14:0 was the most abundant in the healthy individuals. Considering the relative percentages of 3-OH-C-12:0, 3-OH-C-14:0, 3OH-C-i17:0, and 3-OH-C-17:0, 95.6% of all cases were correctly classified as healthy individuals or periodontitis patients by means of discriminant analysis. The sensitivity, specificity, positive predictive value and negative predictive value of 3-OH FA analysis in diagnosing peridontitis were, respectively, 0.92, 1.00, 1.00, and 0.90. The results indicate that 3-OH FA analysis of saliva samples is a useful diagnostic method in chronic periodontitis.

• Författare: R Ferrando; Bogumila Szponar; A Sanchez; Lennart Larsson; P L Valero-Guillen
• Avdelning/ar: Avdelningen för medicinsk mikrobiologi
• Publiceringsår: 2005
• Språk: Engelska
• Sidor: 285-291
• Publikation/Tidskrift/Serie: Journal of Microbiological Methods
• Volym: 62
• Issue: 3
• Länkar: http://dx.doi.org/10.1016/j.mimet.2005.04.014
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Microbiology in the medical area
• Nyckelord: gas chronnatography-mass spectrometry; acids; anaerobic gram-negative bacteria/periodontal pathogens; 3-hydroxy fatty; periodontitis/etiology; microbial chemical; inarkers
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1872-8359