Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy

In English We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by a ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.