Patient-specific Glucose Metabolism Models for Model Predictive Control of T1DM Glycemia

In English The development of a predictive control algorithm for glycaemia regulation in diabetic subjects requires patient-specific models of the glucose metabolism which are physiologically relevant, parsimonious, yet able to accurately forecast blood glucose.

Given the measured data: total plasma insulin mIU/L; plasma glucose mg/dL; plasma glucose rate of appearance after intestinal absorption mg/kg/min, the objective was to find individualized, simple and plausible glucose-insulin interaction models suitable for exploitation in a MPC framework.