The calpain inhibitor VI prevents apoptosis of adult motor neurons
Författare
Summary, in English
Motor neuron cell death was studied in organotypic cultures of adult spinal cord slices from the mouse. Six hours after excision, many motor neuron nuclei displayed apoptotic features including nuclear and chromatin condensation. At this time point, many motor neurons also exhibited immunoreactivity to calpain II. Both the calpain inhibitor VI and ethyleneglycol-bis(beta-aminoethyl ether) N,N,N',N'-tetraacetic acid (EGTA) prevented the appearance of apoptotic nuclei whereas the pan caspase inhibitor Z-VAD.fmk had no effect. The results suggest that calpain is required for apoptosis of motor neurons and that this type of apoptosis is independent of caspase activation.
Avdelning/ar
Publiceringsår
2005
Språk
Engelska
Sidor
1065-1068
Publikation/Tidskrift/Serie
NeuroReport
Volym
16
Issue
10
Dokumenttyp
Artikel i tidskrift
Förlag
Lippincott Williams & Wilkins
Ämne
- Neurosciences
Nyckelord
- culture
- organ
- motor neurons
- caspase
- calpain inhibitor
- apoptosis
- calpain
- spinal cord
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1473-558X