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The calpain inhibitor VI prevents apoptosis of adult motor neurons

Författare:
  • HamidReza Momeni
  • Martin Kanje
Publiceringsår: 2005
Språk: Engelska
Sidor: 1065-1068
Publikation/Tidskrift/Serie: Neuroreport
Volym: 16
Nummer: 10
Dokumenttyp: Artikel
Förlag: Lippincott Williams & Wilkins

Sammanfattning

Motor neuron cell death was studied in organotypic cultures of adult spinal cord slices from the mouse. Six hours after excision, many motor neuron nuclei displayed apoptotic features including nuclear and chromatin condensation. At this time point, many motor neurons also exhibited immunoreactivity to calpain II. Both the calpain inhibitor VI and ethyleneglycol-bis(beta-aminoethyl ether) N,N,N',N'-tetraacetic acid (EGTA) prevented the appearance of apoptotic nuclei whereas the pan caspase inhibitor Z-VAD.fmk had no effect. The results suggest that calpain is required for apoptosis of motor neurons and that this type of apoptosis is independent of caspase activation.

Disputation

Nyckelord

  • Biology and Life Sciences
  • culture
  • organ
  • motor neurons
  • caspase
  • calpain inhibitor
  • apoptosis
  • calpain
  • spinal cord

Övriga

Published
Yes
  • ISSN: 0959-4965

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