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Can histology solve the riddle of non-functioning electrodes; factors influencing the biocompatibillity of brain machine interfaces.

Författare

Redaktör

  • Jens Schouenborg
  • Nils Danielsen
  • Martin Garwicz

Summary, in English

Neural interfaces hold great promise to become invaluable clinical and diagnostic tools in the

near future. However, the biocompatibility and the long-term stability of the implanted interfaces are far

from optimized. There are several factors that need to be addressed and standardized when improving

the long-term success of an implanted electrode. We have chosen to focus on three key factors when

evaluating the evoked tissue responses after electrode implantation into the brain: implant size,

fixation mode, and evaluation period. Further, we show results from an ultrathin multichannel wire

electrode that has been implanted in the rat cerebral cortex for 1 year.

To improve biocompatibility of implanted electrodes, we would like to suggest that free-floating, very

small, flexible, and, in time, wireless electrodes would elicit a diminished cell encapsulation. We would

also like to suggest standardized methods for the electrode design, the electrode implantation method,

and the analyses of cell reactions after implantation into the CNS in order to improve the long-term

success of implanted neural interfaces.

Publiceringsår

2011

Språk

Engelska

Sidor

181-189

Publikation/Tidskrift/Serie

Progress in Brain Research

Volym

194

Dokumenttyp

Del av eller Kapitel i bok

Förlag

Elsevier

Ämne

  • Neurosciences

Nyckelord

  • cell morphology
  • brain
  • electrode
  • neural cell
  • micromotion
  • cell encapsulation

Status

Published

Forskningsgrupp

  • Neuronano Research Center (NRC)

ISBN/ISSN/Övrigt

  • ISSN: 0079-6123