Coeliac disease in children: a social epidemiological study in Sweden
Författare
Summary, in English
Aim: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two. Methods: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792 401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics. Results: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82), but not in girls OR 0.87 (95% CI 0.68-1.12). We found a considerable geographical variation in disease risk (i.e. intra-municipality correlation approximate to 10%) that was not explained by individual characteristics. Conclusions: Low SEP is associated with CD in boys but not in girls. Also, CD appears to be conditioned by geographical area of residence. While our study represents an innovative contribution to the epidemiology of CD in children, the reasons for the observed geographical and socioeconomic differences could be speculated but are still unknown.
Avdelning/ar
Publiceringsår
2012
Språk
Engelska
Sidor
185-191
Publikation/Tidskrift/Serie
Acta Pædiatrica
Volym
101
Issue
2
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Pediatrics
Nyckelord
- Child
- Coeliac disease
- Infant
- Risk factors
- Socioeconomic factors
Status
Published
Forskningsgrupp
- Social Epidemiology
- Celiac Disease and Diabetes Unit
ISBN/ISSN/Övrigt
- ISSN: 1651-2227