Meny

Javascript is not activated in your browser. This website needs javascript activated to work properly.
Du är här

Normative childhood repetitive routines and obsessive compulsive symptomatology in 6-year-old twins

Författare:
  • Derek Bolton (Professor)
  • Fruhling Rijsdijk (Doctor)
  • Thalia Eley (Doctor)
  • Thomas O'Connor (Professor)
  • Jacqueline Briskman (Ms)
  • Sean Perrin (Dr)
Publiceringsår: 2009
Språk: Engelska
Sidor: 1139-1146
Publikation/Tidskrift/Serie: Journal of Child Psychology and Psychiatry
Volym: 50
Nummer: 9
Dokumenttyp: Artikel
Förlag: Wiley-Blackwell

Sammanfattning

Background: To investigate the association between normative repetitive routines of childhood and
paediatric obsessive compulsive symptom syndrome (OCSS) and the extent to which it is genetically
mediated. Methods: In a two-phase design a community sample of 4,662 6-year-old twin-pairs were
sampled and 854 pairs were assessed in the second phase for normative repetitive routines using the
Childhood Routines Inventory (CRI) and for OCSS by maternal-informant diagnostic interview. The
OCSS phenotype was defined using standard diagnostic criteria for obsessive compulsive disorder, though regardless of impairment. Results: In the bivariate model, correlation between the CRI defined phenotype and the OCSS phenotype was estimated to be .40 (95% CI .27–.50), and this correlation was attributable wholly to additive genetic effects. The bivariate model also provided estimates of heritability of the two phenotypes separately: 55% (95% CI 80–89%) for the OCSS phenotype, with the remaining variance attributable mainly to non-shared environment, and 50% (95% CI 39–62%) for CRI assessed normative repetitive routines of childhood, with 36% of the remaining variance attributable to shared environment and 14% to non-shared. Conclusions: The moderate correlation between normative childhood repetitive routines and obsessive compulsive symptomatology, attributable to genetic factors, is consistent with the hypothesis that high levels of this trait in young children constitute a risk factor for the development of obsessive compulsive symptoms.

Disputation

Nyckelord

  • Social Sciences
  • Obsessive compulsive disorder
  • Childhood Routines Inventory
  • children
  • twins
  • genetics.

Övriga

Published
Yes

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen