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Amphiregulin acts as an autocrine survival factor for adult sensory neurons

Författare:
  • Anna Nilsson
  • Martin Kanje
Publiceringsår: 2005
Språk: Engelska
Sidor: 213-218
Publikation/Tidskrift/Serie: Neuroreport
Volym: 16
Nummer: 3
Dokumenttyp: Artikel
Förlag: Lippincott Williams & Wilkins

Sammanfattning

We studied the effect of amphiregulin on axonal outgrowth and survival in sensory neurons in organ cultured and dissociated mouse dorsal root ganglia (DRG). Amphiregulin at 20 ng/ml stimulated axonal outgrowth in both preparations. The EGF receptor inhibitor AG1478 inhibited outgrowth at 10 mu M but not at 1 mu M, where it abolished the stimulatory effects of amphiregulin. Fluoro-Jade staining and neuronal counting showed that more neurons survived in culture in the presence of amphiregulin while AG1478 at 10 mu M but not 1 mu M increased cell death. Small and medium sized neurons were immunopositive for both amphiregulin and the EGF receptor. Taken together these results suggest that amphiregulin can act as an autocrine survival factor for sensory neurons and stimulate axonal outgrowth through the EGF receptor.

Disputation

Nyckelord

  • Science General
  • nerve growth factors
  • sensory neurons
  • nerve regeneration
  • receptor
  • EGF
  • spinal ganglia
  • axotomy
  • axons
  • amphiregulin
  • apoptosis

Övriga

Published
Yes
  • ISSN: 0959-4965

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