Beyond α-synuclein transfer: pathology propagation in Parkinson's disease.
Författare
Summary, in English
α-Synuclein (α-syn) is the most abundant protein found in Lewy bodies, a hallmark of Parkinson's disease (PD), and can aggregate to form toxic oligomers and fibrillar structures. Recent studies have shown that α-syn can be transmitted between neurons and can seed the formation of toxic aggregates in recipient neurons in a prion-like manner. In addition, it is known that Lewy body pathology may spread gradually and systematically from the peripheral or enteric nervous system or olfactory bulb to specific brain regions during progression of idiopathic PD. It is therefore conceivable that α-syn species could act as seeds that drive PD progression. Here, we review recent advances from studies of α-syn cell-to-cell transfer, the current understanding of α-syn toxicity, and how these relate to progression of PD pathology.
Avdelning/ar
Publiceringsår
2012
Språk
Engelska
Sidor
248-255
Publikation/Tidskrift/Serie
Trends in Molecular Medicine
Volym
18
Issue
5
Fulltext
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Cell and Molecular Biology
Status
Published
Forskningsgrupp
- Neural Plasticity and Repair
- Molecular Neurobiology
ISBN/ISSN/Övrigt
- ISSN: 1471-4914