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Contribution of catalase to hydrogen peroxide resistance in Enterococcus faecalis.

In English

Författare

Summary, in English

Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed when the bacterium is supplied with heme. We have used this heme dependency of catalase activity and mutants deficient in KatA and Npr to investigate the role of the catalase in resistance against exogenous and endogenous hydrogen peroxide stress. The results demonstrate that in the presence of environmental heme catalase contributes to the protection against toxic effects of hydrogen peroxide.

Publiceringsår

2012

Språk

Engelska

Sidor

160-164

Publikation/Tidskrift/Serie

FEMS Microbiology Letters

Volym

331

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Oxford University Press

Ämne

  • Microbiology

Nyckelord

  • oxidative stress
  • heme
  • NADH peroxidase
  • streptococci

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1574-6968