Craniofacial dysmorphology in Swedish schizophrenia patients
Författare
Summary, in English
Objective: To perform detailed assessments of craniofacial dysmorphology in individuals with schizophrenia and controls in Sweden, in order to further elucidate the neurodevelopmental origins of schizophrenia. Method: We performed detailed, anthropometric assessments of craniofacial dysmorphology in male patients with schizophrenia (n = 24), healthy controls (n = 16), and patients' siblings with schizophrenia (n = 2) in Sweden, while remaining as blind as possible to schizophrenia/control status. Results: Individuals with schizophrenia evidenced significantly more craniofacial dysmorphology than controls, especially in the ears and mouth. At a group level, there was a dose-response type relationship between total dysmorphology score and patient/control status. Conclusion: The consistency of results across multiple studies supports the hypothesis that individuals with schizophrenia have increased rates of prenatal developmental disturbances. The presence of a dose-response type relationship between total dysmorphology score and patient/control status supports the importance of neurodevelopmental disturbance as a contributory cause of schizophrenia.
Avdelning/ar
Publiceringsår
2005
Språk
Engelska
Sidor
202-207
Publikation/Tidskrift/Serie
Acta Psychiatrica Scandinavica
Volym
111
Issue
3
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Psychiatry
Nyckelord
- schizophrenia
- aetiology
- human development
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1600-0447