Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

Författare

  • Anna Mansour
  • Grazia Abou-Ezzi
  • Ewa Sitnicka Quinn
  • Sten Eirik W Jacobsen
  • Abdelilah Wakkach
  • Claudine Blin-Wakkach

Summary, in English

Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activity, to investigate the role of osteoblasts (OBLs) and OCLs in the HSC niche formation. The absence of OCL activity resulted in a defective HSC niche associated with an increased proportion of mesenchymal progenitors but reduced osteoblastic differentiation, leading to impaired HSC homing to the BM. Restoration of OCL activity reversed the defect in HSC niche formation. Our data demonstrate that OBLs are required for establishing HSC niches and that osteoblastic development is induced by OCLs. These findings broaden our knowledge of the HSC niche formation, which is critical for understanding normal and pathological hematopoiesis.

Publiceringsår

2012

Språk

Engelska

Sidor

537-549

Publikation/Tidskrift/Serie

Journal of Experimental Medicine

Volym

209

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Rockefeller University Press

Ämne

  • Cell and Molecular Biology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1540-9538