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Standard Guidelines for the Chromosome-Centric Human Proteome Project

Författare:
  • Young-Ki Paik
  • Gilbert S. Omenn
  • Mathias Uhlen
  • Samir Hanash
  • György Marko-Varga
  • Ruedi Aebersold
  • Amos Bairoch
  • Tadashi Yamamoto
  • Pierre Legrain
  • Hyoung-Joo Lee
  • Keun Na
  • Seul-Ki Jeong
  • Fuchu He
  • Pierre-Alain Binz
  • Toshihide Nishimura
  • Paul Keown
  • Mark S. Baker
  • Jong Shin Yoo
  • Jerome Garin
  • Alexander Archakov
  • John Bergeron
  • Ghasem Hosseini Salekdeh
  • William S. Hancock
Publiceringsår: 2012
Språk: Engelska
Sidor: 2005-2013
Publikation/Tidskrift/Serie: Journal of Proteome Research
Volym: 11
Nummer: 4
Dokumenttyp: Artikel
Förlag: American Chemical Society

Sammanfattning

The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome. The C-FIPP consortium was established to organize a collaborative network among the research teams responsible for protein mapping of individual chromosomes and to identify compelling biological and genetic mechanisms influencing colocated genes and their protein products. The C-HPP aims to foster the development of proteome analysis and integration of the findings from related molecular -omics technology platforms through collaborations among universities, industries, and private research groups. The C-HPP consortium leadership has elicited broad input for standard guidelines to manage these international efforts more efficiently by mobilizing existing resources and collaborative networks. The C-HPP guidelines set out the collaborative consensus of the C-HPP teams, introduce topics associated with experimental approaches, data production, quality control, treatment, and transparency of data, governance of the consortium, and collaborative benefits. A companion approach for the Biology and Disease-Driven HPP (B/D-HPP) component of the Human Proteome Project is currently being organized, building upon the Human Proteome Organization's organ-based and biofluid-based initiatives (www.hupo.org/research). The common application of these guidelines in the participating laboratories is expected to facilitate the goal of a comprehensive analysis of the human proteome.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • antibody
  • Biology/Disease-Driven Human Proteome Project
  • Chromosome-Centric Human Proteome Project
  • Human Genome Project
  • Human
  • Proteome Project
  • Human Proteome Organization
  • knowledge-base
  • mass
  • spectrometry

Övriga

Published
Yes
  • ISSN: 1535-3893

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