Synthesis of a C3-symmetric macrocycle with alternating sugar amino acid and tyrosine residues
Författare
Summary, in English
A C3-symmetric macrocycle with alternating sugar amino acid and tyrosine residues was synthesized in seven steps from tyrosine tert-butyl ester and a sugar amino acid precursor derived from D-glucosamine. An Fmoc-protected D-glucosamine derivative was oxidized at C-6 to give the sugar amino acid, which was immediately coupled to tyrosine tert-butyl ester to produce an orthogonally protected building block. This building block was subsequently elongated to the trimer via the dimer, and finally cyclized to give the C3-symmetric macrocycle.
Avdelning/ar
Publiceringsår
2005
Språk
Engelska
Sidor
991-993
Publikation/Tidskrift/Serie
Tetrahedron Letters
Volym
46
Issue
6
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Organic Chemistry
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0040-4039