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Plasminogen is a critical host pathogenicity factor for group A streptococcal infection

  • HM Sun
  • Ulrika Ringdahl
  • JW Homeister
  • WP Fay
  • NC Engleberg
  • AY Yang
  • LS Rozek
  • XX Wang
  • Ulf Sjöbring
  • D Ginsburg
Publiceringsår: 2004
Språk: Engelska
Sidor: 1283-1286
Publikation/Tidskrift/Serie: Science
Volym: 305
Nummer: 5688
Dokumenttyp: Artikel
Förlag: American Association for the Advancement of Science (AAAS)


Group A streptococci, a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other mammalian species, including mouse. Here, a transgene expressing human plasminogen markedly increased mortality in mice infected with streptococci, and this susceptibility was dependent on bacterial streptokinase expression. Thus, streptokinase is a key pathogenicity factor and the primary determinant of host species specificity for group A streptococcal infection. In addition, local fibrin clot formation may be implicated in host defense against microbial pathogens.



  • Medicine and Health Sciences


  • ISSN: 0036-8075

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