The dynamics of genomic-length DNA molecules in 100-nm channels
Författare
Summary, in English
We show that genomic-length DNA molecules imaged in nano-channels have an extension along the channel that scales linearly with the contour length of the polymer, in agreement with the scaling arguments developed by de Gennes for self-avoiding confined polymers. This fundamental relationship allows us to measure directly the contour length of single DNA molecules confined in the channels, and the statistical analysis of the dynamics of the polymer in the nanochannel allows us to compute the SD of the mean of the extension. This statistical analysis allows us to measure the extension of A DNA multimers with a 130-nm SD in 1 min.
Avdelning/ar
Publiceringsår
2004
Språk
Engelska
Sidor
10979-10983
Publikation/Tidskrift/Serie
Proceedings of the National Academy of Sciences
Volym
101
Issue
30
Dokumenttyp
Artikel i tidskrift
Förlag
National Academy of Sciences
Ämne
- Condensed Matter Physics
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1091-6490