Urinary bladder contraction and relaxation: Physiology and pathophysiology
Författare
Summary, in English
The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its ability to contract over a large length interval and to relax determines the bladder function during filling and micturition. These processes are regulated by several external nervous and hormonal control systems, and the detrusor contains multiple receptors and signaling pathways. Functional changes of the detrusor can be found in several clinically important conditions, e.g., lower urinary tract symptoms (LUTS) and bladder outlet obstruction. The aim of this review is to summarize and synthesize basic information and recent advances in the understanding of the properties of the detrusor smooth muscle, its contractile system, cellular signaling, membrane properties, and cellular receptors. Alterations in these systems in pathological conditions of the bladder wall are described, and some areas for future research are suggested.
Publiceringsår
2004
Språk
Engelska
Sidor
935-986
Publikation/Tidskrift/Serie
Physiological Reviews
Volym
84
Issue
3
Dokumenttyp
Artikel i tidskrift
Förlag
American Physiological Society
Ämne
- Physiology
Status
Published
Forskningsgrupp
- Vascular Physiology
ISBN/ISSN/Övrigt
- ISSN: 1522-1210