Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Phylogenetic analysis of the vertebrate galectin family

Författare

  • D Houzelstein
  • IR Goncalves
  • AJ Fadden
  • SS Sidhu
  • DNW Cooper
  • K Drickamer
  • Hakon Leffler
  • F Poirier

Summary, in English

Galectins form a family of structurally related carbohydrate binding proteins (lectins) that have been identified in a large variety of metazoan phyla. They are involved in many biological processes such as morphogenesis, control of cell death, immunological response, and cancer. To elucidate the evolutionary history of galectins and galectin-like proteins in chordates, we have exploited three independent lines of evidence: (i) location of galectin encoding genes (LGALS) in the human genome; (ii) exon-intron organization of galectin encoding genes; and (iii) sequence comparison of carbohydrate recognition domains (CRDs) of chordate galectins. Our results suggest that a duplication of a mono-CRD galectin gene gave rise to an original bi-CRD galectin gene, before or early in chordate evolution. The N-terminal and C-terminal CRDs of this original galectin subsequently diverged into two different subtypes, defined by exon-intron structure (F4-CRD and F3-CRD). We show that all vertebrate mono-CRD galectins known to date belong to either the F3- or F4-subtype. A sequence of duplication and divergence events of the different galectins in chordates is proposed.

Publiceringsår

2004

Språk

Engelska

Sidor

1177-1187

Publikation/Tidskrift/Serie

Molecular biology and evolution

Volym

21

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

Oxford University Press

Ämne

  • Immunology in the medical area
  • Microbiology in the medical area

Nyckelord

  • chordate
  • vertebrate
  • galectin
  • Lgals
  • evolution

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0737-4038