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Heme A biosynthesis

Publiceringsår: 2012
Språk: Engelska
Sidor: 920-927
Publikation/Tidskrift/Serie: Biochimica Et Biophysica Acta-Bioenergetics
Volym: 1817
Nummer: 6
Dokumenttyp: Artikel
Förlag: Elsevier Science Bv


Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side group at position C8 of the porphyrin macrocycle. Heme A synthase catalyzes the formation of the formyl side group and is a poorly understood heme-containing membrane bound atypical monooxygenase. This review presents our current understanding of heme A synthesis at the molecular level in mitochondria and aerobic bacteria. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. (C) 2012 Elsevier B.V. All rights reserved.



  • Biological Sciences
  • Cytochrome biogenesis
  • Heme synthesis
  • CtaA
  • COX15
  • Oxidase assembly


  • ISSN: 0005-2728

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