Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.
Författare
Summary, in English
Stretch is essential for maintaining the contractile phenotype of vascular smooth muscle cells, and small non-coding microRNAs are known to be important in this process. Using a Dicer knockout model, we have previously reported that microRNAs are essential for stretch-induced differentiation and regulation of L-type calcium channel expression. The aim of this study was to investigate the importance of the smooth muscle-enriched miR-143/145 microRNA cluster for stretch-induced differentiation of the portal vein.
Publiceringsår
2015
Språk
Engelska
Sidor
133-143
Publikation/Tidskrift/Serie
Acta Physiologica
Volym
215
Issue
3
Fulltext
- Available as PDF - 727 kB
- Download statistics
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Cell and Molecular Biology
Status
Published
Forskningsgrupp
- Vascular Physiology
- Cellular Biomechanics
- Molecular Vascular Physiology
ISBN/ISSN/Övrigt
- ISSN: 1748-1716