Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project

Summary, in English

OBJECTIVE: To study the association between polymorphisms in the angiotensin converting enzyme (ACE) gene and angiotensinogen (AGT) gene and hypertension and/or type 2 diabetes in a community population. PATIENTS AND METHODS: The insertion (I)/deletion (D) polymorphism of the ACE gene and the M235T polymorphism of the AGT gene were genotyped in 773 nondiabetic individuals with hypertension, 193 normotensive patients with type 2 diabetes, 243 patients with type 2 diabetes and hypertension, and in 820 normotensive control individuals identified in a community-based study. RESULTS: The DD genotype was associated with hypertension in individuals less than 70 years [odds ratio (OR) = 1.54, confidence interval (CI) = 1.09-2.18] and remained so when patients with type 2 diabetes were excluded from the analysis (OR = 1.45, CI = 1.01-2.09). The strongest association was with the combination of type 2 diabetes and hypertension (OR = 2.19, CI = 1.09-4.38). There was no association with type 2 diabetes without hypertension. No association was observed between the M235T variant or the 3'-microsatellite polymorphism of the AGT gene and hypertension. CONCLUSION: The D-allele of the ACE gene ID polymorphism increases susceptibility to hypertension, particularly when associated with type 2 diabetes. No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension.

• Författare: Kristina Bengtsson Boström; Marju Orho-Melander; Ulf Lindblad; Olle Melander; Erik Bøg-Hansen; Jonas Ranstam; Lennart Råstam; Leif Groop
• Avdelning/ar: Translationell Muskel Forskning; Community Medicine; Kardiovaskulär forskning - hypertoni; Institutionen för kliniska vetenskaper, Malmö; Ortopedi, Lund
• Publiceringsår: 1999
• Språk: Engelska
• Sidor: 1569-1575
• Publikation/Tidskrift/Serie: Journal of Hypertension
• Volym: 17
• Issue: 11
• Dokumenttyp: Artikel i tidskrift
• Förlag: Lippincott Williams & Wilkins
• Ämne: Cardiac and Cardiovascular Systems
• Nyckelord: Hypertension; Diabetes mellitus; Polymorphism; Peptidyl-dipeptidase A; Gene; Angiotensinogen; Genetic determinism; Human; Peptidyl-dipeptidases; Peptidases; Hydrolases; Enzyme; Cardiovascular disease; Endocrinopathy
• Status: Published
• Forskningsgrupp: Genomics, Diabetes and Endocrinology; Community Medicine; Cardiovascular Research - Hypertension
• ISBN/ISSN/Övrigt: ISSN: 1473-5598