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Memory aging and brain maintenance

Författare:
  • Lars Nyberg
  • Martin Lövdén
  • Katrine Riklund
  • Ulman Lindenberger
  • Lars Backman
Publiceringsår: 2012
Språk: Engelska
Sidor: 292-305
Publikation/Tidskrift/Serie: Trends in Cognitive Sciences
Volym: 16
Nummer: 5
Dokumenttyp: Artikel
Förlag: Elsevier

Sammanfattning

Episodic memory and working memory decline with advancing age. Nevertheless, large-scale population-based studies document well-preserved memory functioning in some older individuals. The influential 'reserve' notion holds that individual differences in brain characteristics or in the manner people process tasks allow some individuals to cope better than others with brain pathology and hence show preserved memory performance. Here, we discuss a complementary concept, that of brain maintenance (or relative lack of brain pathology), and argue that it constitutes the primary determinant of successful memory aging. We discuss evidence for brain maintenance at different levels: cellular, neurochemical, gray- and white-matter integrity, and systems-level activation patterns. Various genetic and lifestyle factors support brain maintenance in aging and interventions may be designed to promote maintenance of brain structure and function in late life.

Disputation

Nyckelord

  • Medicine and Health Sciences

Övrigt

Published
Yes
  • ISSN: 1364-6613

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