Viewpoints in Clinical Proteomics - when will proteomics deliver clinically useful information?

Summary, in English

Proteomics has not delivered biomarkers of clinical value, despite massive efforts. The technologies that are emerging today have, however, the power to reach deep into proteomes and to identify patterns associated with different diseases. The study design is then crucial and sample quality, bioinformatic approaches, pre-validation, using independent patient cohort, need to attract increased attention before proteomics will contribute to the needs of personalized medicine.

• Författare: Carl Borrebaeck
• Avdelning/ar: Institutionen för immunteknologi; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2012
• Språk: Engelska
• Sidor: 343-345
• Publikation/Tidskrift/Serie: Proteomics Clinical Applications
• Volym: 6
• Issue: 7-8
• Länkar: http://dx.doi.org/10.1002/prca.201200020
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Cell and Molecular Biology
• Nyckelord: over-fitting; biobanks; pre-validation; bioinformatics; Signatures
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1862-8354